Date of Award

12-2016

Degree Type

Thesis

Degree Name

Master of Science

Department

Clinical Sciences

Program

Training and Human Performance Improvement

First Advisor/Chairperson

Paul Mann

Second Advisor

Josh Sharp

Third Advisor

Cathy Bammert

Abstract

Invasive disease caused by Streptococcus pneumoniae and Staphylococcus aureus is associated with nasal carriage of these bacteria. Use of a pneumococcal conjugate vaccine (PCV) in children altered nasal carriage rates and reduced infections due to S. pneumonia. Similar studies demonstrate that there is an inverse correlation between S. pneumoniae and S. aureus nasal carriage in children, but this inverse correlation has not been extensively investigated adults. The PCV is now approved for use in adults, a group more likely to be colonized with S. aureus. To investigate the impact of PCV vaccination on S. aureus carriage in adults, the clinical evaluation of a multiplex Real Time PCR method to simultaneously detect very low levels of S. pneumoniae and S. aureus from the same nasal sample is described.

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