Abstract
The purpose of this ongoing research project was to learn more about the compound Thioflavin T by developing methods using a UV/Vis spectrophotometer to study how this molecule interacts with other biomolecules. Thioflavin T (ThT), is a fluorescent dye that can bind proteins and nucleic acids and can be used to probe protein aggregation and unique nucleic acid secondary structures. It can be used as a biosensor to detect specific abnormal proteins called amyloid fibrils in biological samples. In this project, we will investigate how thioflavin T interacts with different nucleic acid secondary structures with the goal of developing a ThT-based biosensor for nucleic acid structures.
Class Standing
Freshman
Department
Chemistry
Faculty Advisor
Philip Yangyuoru
Faculty Advisor Email
pyangyuo@nmu.edu
Date
2022
Recommended Citation
Nunn, Caitlyn B. and Yangyuoru, Philip, "Using Thioflavin T as a biosensor for the detection of nucleic acid secondary structures" (2022). Celebration of Student Scholarship. 50.
https://commons.nmu.edu/celebration_student_scholarship/50