Journal Title/Source
Neurology Research International
Publication Date
1-2012
Volume
2012
Page Numbers
1-6
Document Type
Journal Article
Department
Biology
Abstract
The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models of colon cancer and melanoma, a decline in the expression and secretion of leptin resulted in a reduction of tumor growth. In these models, positive mental stimulation through environmental enrichment decreased leptin secretion and improved tumor outcome. This review explores the link between leptin and glioblastoma
Recommended Citation
Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, and Robert J. Winn. "Leptin Promotes Glioblastoma" Neurology Research International.2012 (2012). Available at: http://works.bepress.com/johnathan_lawrence/5