Date of Award

3-2025

Degree Type

Thesis

Degree Name

Master of Science

Department

Psychological Science

Program

Psychological Science (MS)

First Advisor/Chairperson

Amber LaCrosse

Abstract

One of the most common neurodevelopmental disorders is Attention Deficit Hyperactivity Disorder (ADHD), which is often co-occurring with symptoms of depression and anxiety. The misdiagnosis and overdiagnosis of ADHD is agreed to be a prevalent problem. The methylenetetrahydrofolate reductase (MTHFR) gene has been identified as a possible contributor to ADHD. The goal of this research is to decrease the frequency at which ADHD is misdiagnosed by investigating the correlation between the MTHFR gene at the single nucleotide polymorphism (SNP) C677T to ADHD and anxiety. A group of 80 participants’ DNA samples were collected through cheek swabs following IRB approval. Participants completed several questionnaires to assess their signs and symptoms of ADHD. DNA amplification of the MTHFR gene was achieved using loop-mediated isothermal amplification (LAMP), with colorimetric visualization to determine the presence of mutations. Results were analyzed using Fisher’s exact tests to explore the associations between ADHD, anxiety, and MTHFR mutation. The hypothesis is that the presence of the C677T SNP in the MTHFR gene would positively correlate with reported symptoms of anxiety and ADHD. This study aimed to add a genetic component to the testing for ADHD, by assessing whether mutations in the MTHFR gene are a factor for disorders such as ADHD and anxiety. Results from statistical analysis yielded no significant findings across any measure.

Access Type

Open Access

Additional Files
Heba Mehmood.pdf (35 kB)
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Psychology Commons

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