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The purpose of this study was to explore if a mass-spring-damper model can simulate trunk kinematics during running with the purpose of predicting ground reaction forces (GRF). Vertical GRF and trunk kinematics was measured for 16 participants during running at 2-5 m·s-1. The vertical trunk acceleration were used to simulate the acceleration of a mass-spring-damper model’s upper mass and generate the eight model parameters required to predict GRF. Mean squared errors between 0.8 ± 0.4 and 0.9 ± 0.5 m·s-2 and between 19.1 ± 7.0 and 27.9 ± 14.5 N·kg-1 were observed for the trunk acceleration and GRF respectively. Despite excellent trunk acceleration simulations, poor GRF predictions indicated that a simple mass-spring-damper model is shortcoming to predict variations in distinct loading features across different running speeds.