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Moving on slopes is part of daily living locomotion, but also several sport disciplines are performed on inclined terrain. From a biomechanical perspective locomotion on slopes is a challenging task as additional work has to be done compared to locomotion on flat terrain. Moving downwards supports the locomotion due to gravity, however, steep slopes often lead to high speeds caused by the transfer of potential to kinetic energy. Then locomotion is accompanied with the challenge to control speed. Another issue is the aspect of joint loading when moving on slopes. An increase of potential or kinetic energy is associated with an enhancement of work done by the joint structures. The purpose of the presentation is to characterize the specificity and challenges when moving on slopes from a biomechanical perspective including performance, coordination, safety and joint loading in daily movement and sport related tasks.