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The current study examined the effects of the NewGait device on walking performance in persons with multiple sclerosis (MS). Eight MS patients participated in this study. Pre- and post-testing assessed kinematic gait variables (step width, length, and speed), ankle range of motion, and rating of perceived exertion (RPE). Participants completed an 8-week physical therapy (PT) protocol aimed to improve gait and balance, with the experimental group wearing the NewGait device. Repeated measures mixed ANOVA showed no main effects between the gait variables or between groups. Post-hoc paired t-tests indicated that the NewGait device elicited meaningful change in left and right step length and speed. The NewGait device may be a promising rehabilitation device to help induce positive walking performance changes in persons with MS.