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Elite athletes are underrepresented in scientific research and evidence from group-based studies may not be applicable to individual elite athletes. The purpose of this study was to investigate mechanical determinants of sprint performance in elite sprinters using inter- and intra-individual approaches. Six elite and six sub-elite sprinters performed maximal effort sprint acceleration trials and their force-velocity-power profiles were computed. Theoretical maximum velocity, power and the ratio of force were greater in the elite than the sub-elite athletes. Within the elite group, individuals achieved their fastest times through greater theoretical maximum horizontal force with only small differences in theoretical maximum velocity between the best and worst trials. Practitioners should consider these intra-individual data when coaching and programming for elite athletes.