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Validation is a critical component to the scientific method and translation of scientific knowledge, algorithms, and technology to real-world sporting or clinical settings, and requires rigorous testing by multiple stakeholders. This process can take decades to have an influence on clinical practice. Validation is also a crucial part of translating technology and science into commercial application, although in this context validation needs to take into account usability, manufacturing, price/performance trade-offs, finding a product-market fit and determining your value proposition in the market place. This discussion will draw on the experience of a diverse panel to highlight some of the challenges of translating science to commercial applications. By illustrating through examples from the diverse and experienced panel members, various validation methods and their implications for commercialising a product or algorithm, compared with validating a hypothesis, will be covered.