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Compensational gait mechanisms, as an increased mediolateral trunk lean, are associated with the development of lower back pain, which is common among individuals with transtibial amputation (TTA). Therefore, the aim of this study was to investigate if different prosthetic ankle devices influence mediolateral trunk angles during gait in TTA. Six TTA and six controls walked in the level and on a positive and negative 5° inclined instrumented ramp using a rigid (RIG), a hydraulic (HYD) and a microprocessor (MPC) ankle component (Chas A Blatchford and Sons, Basingstoke, UK). Prosthetic design did not significantly affect the mediolateral trunk lean in any of the three slope conditions. Therefore, the different prosthetic ankle devices seem to play a minor role for mediolateral trunk lean adaptations. Their potential to reduce lower back pain needs further investigation.