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This study examines students’ academic performance before and after the outbreak of the COVID-19 pandemic and associations with performance in introductory biomechanics. Two intact undergraduate biomechanics classes were retrospectively examined: One with in-person instruction (IPI) two semesters before the outbreak of the pandemic and one with online instruction (OI) two semesters after the outbreak of the pandemic. Class performance measures were not significantly different between instruction formats. The students’ GPA was significantly higher after abruptly transferring from face-to-face to online instruction. GPA for three semesters during the pandemic had no association with the biomechanics class performance (r = 0.29, p = 0.19). Therefore, GPA during the pandemic years should be used with caution or in combination with other assessments.