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This aimed to determine if music with specific target beats per minute (bpm) could be used for treadmill running cadence training to alter lower extremity biomechanics and, thus, reduce injury risk. Motion analysis and a synchronized triaxial accelerometer collected data from eighteen runners during treadmill running. Participants ran at a self-selected speed (SS) to determine their baseline cadence. They also ran to music where the bpm of the songs was increased by 5% and 10% over SS cadence. Post hoc tests showed significant differences in heart rate from SS. There were no significant differences between cadence or peak acceleration. In the current study, music was not shown to be a viable method for cadence training in runners. Our findings led to methodology recommendations for future work in using music to effectively improve running cadence.